Triple Action Defense: Combating HIV/AIDS with Abacavir, Dolutegravir, and Lamivudine

Abacavir, dolutegravir, and lamivudine

What is Abacavir, dolutegravir, and lamivudine?

Abacavir, dolutegravir, and lamivudine is a combination medicine that is used to treat the Human Immunodeficiency Virus (HIV). HIV causes acquired immunodeficiency syndrome (AIDS), which results in weak immune systems.

It should be noted that abacavir, dolutegravir and lamivudine is not a cure for either HIV or AIDS. It just helps manage the condition. A person infected with HIV must use this medicine continuously as prescribed by their health practitioner.

This medication is suitable for adults and children who weigh more than 22 pounds or ten kilograms. However, it should not be used alone by those resistant to certain types of medicines.

Additionally, Abacavir, dolutegravir and Lamivudine are also sometimes prescribed for other uses aside from treating HIV such as other viral infections; however, it's best to use drugs only when prescribed by a doctor.


Abacavir, dolutegravir, and lamivudine should not be taken if you have ever had an allergic reaction to any medicine containing abacavir or if you have HLA-B*5701 allele.

This medicine is also not suitable for those who have moderate or severe liver disease or are taking dofetilide (Tikosyn).

If you experience signs of an allergic reaction such as fever, rash, nausea, vomiting, diarrhea, stomach pain; general ill feeling; extreme tiredness; body aches; shortness of breath; cough or sore throat after using this drug then stop immediately and call your physician.

If in the past you had hepatitis B it may return or worsen with the usage of Abacavir, dolutegravir and lamivudine. It is highly recommended that patients undergo frequent liver function tests for several months.

Prior to Medication Use

Before taking Abacavir, dolutegravir, and lamivudine, it is important to make sure you are not allergic to any of the active ingredients. You must also avoid using this medication if you take dofetilide (Tikosyn), have moderate or severe liver disease, have a gene variation called HLA-B*5701 allele that causes an allergic reaction to certain medications.

Make sure you inform your doctor about your medical history including any signs of liver disease or hepatitis B or C. Also mention if you have heart problems such as high blood pressure, diabetes or cholesterol; kidney disease.

It is possible for patients to develop lactic acidosis (a dangerous build-up of lactic acid in their blood) especially if they are overweight and/or a woman. Women should discuss this risk with their doctors.

Women need to undergo pregnancy tests before taking this medicine as it may harm an unborn baby during conception and in the first 12 weeks of pregnancy. Birth control methods must be used by women on Abacavir, dolutegravir, and lamivudine treatment plan due to its ability to affect pregnancies.

In addition to being listed on a registry that tracks effects from antiviral drugs on babies exposed during pregnancies while under treatment plans for HIV/AIDS; Women with HIV or AIDS should not breastfeed babies because even without symptoms the virus can pass through breast milk.

Possible Reactions

Abacavir, dolutegravir, and lamivudine have certain side effects which can make you sick or cause allergic reactions. You must call your doctor right away if you have symptoms of an allergic reaction from two or more of these specific side effect groups:

Group 1 - Fever.

Group 2 - Rash.

Group 3 - Nausea, vomiting, diarrhea, stomach pain.

Group 4 - General ill feeling, extreme tiredness, body aches.

Group 5 - Shortness of breath, cough and sore throat.

If you are not tolerant to medicines containing abacavir or dolutegravir after your first usage then it is recommended never to use this medicine again. Before using Abacavir,dolutegravir and Lamivudine again for any reason It is recommended to consult with your respective doctor. In case of serious side effects like shows other signs of allergic reaction--skin blisters or peeling ,eye redness , swelling in face or throat,trouble breathing,lactic acidosis etc immediately consult with your doctor

Some possible side effects caused by Abacavir,dolutegravir and Lamivudine are: Lactic acidosis that includes unusual muscle pain,trouble breathing ,stomach ache,vomiting,rare heart rate fluctuations,dizziness,cold feeling,tiredness.Liver problems such as loss of appetite around the midsection area,right-sided upper stomach ache,and clay-colored stools along with yellowing eyes.It may also affect the immune system by causing trouble speaking/swallowing eye movement problems or even weakness/swelling in neck/menstrual changes/impotence.

The common side-effects caused by Abacavir,Dolutegrie and Lamivudine are headaches, tiredness ,and trouble sleeping. But these are not the only possible side-effects, there may be others too. Consult with your doctor to know more about them and in case of any serious side-effects consult your doctor right away. In case you have been going through adverse side effects maybe you can report it to FDA at 1-800-FDA-1088 for a safety checkup before continuing medication.

Medication Interactions

Certain medications, when used at the same time with Abacavir, dolutegravir, and lamivudine are not safe. These drugs can alter your blood levels of other medications you take. As a result of this, side effects may increase or the drugs might lose effectiveness.

If you take abacavir, dolutegravir, and lamivudine with any of the following medicines mentioned below, it is recommended to use these medicines 2 hours before or 6 hours after taking abacavir, dolutegravir and lamivudine dose.

- Antacids or laxatives that contain aluminum or magnesium (Maalox, Milk of Magnesia, Mylanta)

- Pepcid Complete

- Rolaids

- The ulcer medicine sucralfate (Carafate)

- Buffered medicine

- Vitamin or mineral supplements that contain 'calcium' or 'iron'

It's important to note that vitamins and mineral supplements containing calcium and iron can be taken at the same time with Abacavir. However it should only be taken if consumed with food.

Abacavir combined with other prescription drugs and over-the-counter medicines like herbal products has significant complications too. It's important to inform your doctor about all forms of medication you have been consuming- past,present as well as future.

Recommended Dosage Guidelines

Abacavir, dolutegravir, and lamivudine is used for the treatment of HIV-1 infection. The dosage depends on the weight and age of the patient.

For adults, a dose of 1 tablet orally once a day is recommended. The tablets for oral suspension must not be used in adults.

For children weighing between 10 to less than 14 kg, a dosage of 4 tablets orally once a day is recommended. For children weighing between 14 to less than 20 kg, it is recommended to take 5 tablets orally once a day. For children weighing from 20 to less than 25 kg, they should take six tablets orally once per day.

For patients who weigh at least 25 kg or more are recommended to take one tablet orally every day. If the weight is less than this amount then it's usually not recommended.

Consequences of Missed Dose: What to Expect?

If you realize that you missed a dose of Abacavir, dolutegravir, and lamivudine, take the medicine as soon as you can.

However, if it is almost time for your next dose, it is better to skip the missed one. Do not take two doses at once.

It's important to get your prescription refilled before running out of medicine completely to avoid missing more doses.

If you happen to miss several doses or stop taking the drug altogether for some time and then start again; be aware that this may lead to a dangerous or even fatal allergic reaction.

Understanding the Ramifications: Effects of Drug Overdose

Abacavir, dolutegravir, and lamivudine are medications widely prescribed in the treatment of HIV-1 infection.

In case of an overdose with these drugs, it is critical to seek immediate medical attention. This can be done by calling the Poison Help line at 1-800-222-1222 or going to the nearest emergency department.

Symptoms may vary depending on several factors such as age and other medical conditions, but may include nausea, vomiting, diarrhea, fatigue or malaise.

Overdose situations should be taken seriously as they can result in severe adverse effects like lactic acidosis or hepatotoxicity. Prompt medical attention can help prevent major complications.

Precautions and Avoidances: Navigating Abacavir, dolutegravir, and lamivudine

Using Abacavir, dolutegravir, and lamivudine will not prevent your disease from spreading.

Do not have unprotected sex or share razors or toothbrushes.

Ask your doctor how to prevent HIV transmission during sex.

Sharing drug or medicine needles is never safe.

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